2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0545S1
    Probenecid-d7 2012598-90-0 98%
    Probenecid-d7 is deuterium-labeled Probenecid (HY-B0545).
    Probenecid-d7
  • HY-B0637S2
    Bezafibrate-13C6 98%
    Bezafibrate-13C6 (BM15075-13C6) is 13C labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
    Bezafibrate-13C6
  • HY-B0682AR
    Mitiglinide calcium hydrate (Standard) 207844-01-7 98%
    Mitiglinide (calcium hydrate) (Standard) is the analytical standard of Mitiglinide (calcium hydrate). This product is intended for research and analytical applications. Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.
    Mitiglinide calcium hydrate (Standard)
  • HY-B0760S1
    Fenofibric acid-13C8 98%
    Fenofibric acid-13C8 (FNF acid-13C8) is 13C labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
    Fenofibric acid-13C8
  • HY-B0760S2
    Fenofibric acid-d4 98%
    Fenofibric acid-d4 (FNF acid-d4) is deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
    Fenofibric acid-d4
  • HY-B0869AR
    Bispyribac sodium (Standard) 125401-92-5
    Bispyribac (sodium) (Standard) is the analytical standard of Bispyribac sodium (HY-B0869A). This product is intended for research and analytical applications. Bispyribac sodium is a selective, orally active, systemic and post-emergence herbicide. Bispyribac sodium reduces SOD levels and inhibits ALS activity. Bispyribac sodium blocks the biosynthesis of branched-chain amino acids, resulting in growth retardation, chlorosis and necrosis of weeds. Bispyribac sodium exerts herbicidal activity against grass, sedge and broadleaf weeds in rice fields. Bispyribac sodium is hepatotoxic and genotoxic.
    Bispyribac sodium (Standard)
  • HY-B0886AR
    Iproniazid (Standard) 54-92-2 98%
    Iproniazid (Standard) is the analytical standard of Iproniazid (HY-B0886A). This product is intended for research and analytical applications. Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity.
    Iproniazid (Standard)
  • HY-B1153AR
    Glafenine hydrochloride (Standard) 65513-72-6 98%
    Glafenine (hydrochloride) (Standard) is the analytical standard of Glafenine (hydrochloride). This product is intended for research and analytical applications. Glafenine (Glafenin) hydrochloride is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine hydrochloride exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine hydrochloride can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine hydrochloride can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF).
    Glafenine hydrochloride (Standard)
  • HY-B1416AR
    Efaroxan hydrochloride (Standard) 89197-00-2 98%
    Efaroxan (hydrochloride) (Standard) is the analytical standard of Efaroxan (hydrochloride). This product is intended for research and analytical applications. Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease.
    Efaroxan hydrochloride (Standard)
  • HY-B1421S2
    Ractopamine-d3 hydrochloride 1219794-72-5 98.30%
    Ractopamine-d3 (LY031537-d3) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs.
    Ractopamine-d3 hydrochloride
  • HY-B1439BR
    Lorglumide sodium (Standard) 1021868-76-7 98%
    Lorglumide sodium salt (Standard) is the analytical standard of Lorglumide sodium salt. This product is intended for research and analytical applications. Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist.
    Lorglumide sodium (Standard)
  • HY-B1580AR
    Calcium propionate, meets analytical specification of E282 (Standard) 4075-81-4
    Calcium propionate, meets analytical specification of E282 (Standard) is the analytical standard of Calcium propionate, meets analytical specification of E282. This product is intended for research and analytical applications. Calcium propionate, meets analytical specification of E282 is an orally active auxiliary agent for preventing milk fever and improving the health of dairy cows. Calcium propionate can be used for research on dairy cow milk fever and subclinical hypocalcemia.
    Calcium propionate, meets analytical specification of E282 (Standard)
  • HY-B1716SA
    L-5-Hydroxytryptophan-d3 hydrate 99.14%
    L-5-Hydroxytryptophan-d3 (L-5-HTP-d3) hydrate is the deuterium labeled L-5-Hydroxytryptophan (HY-B1716). L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.
    L-5-Hydroxytryptophan-d3 hydrate
  • HY-B1745AR
    Pyridoxylamine dihydrochloride (Standard) 524-36-7 99.09%
    Pyridoxylamine (dihydrochloride) (Standard) is the analytical standard of Pyridoxylamine (dihydrochloride). This product is intended for research and analytical applications. Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
    Pyridoxylamine dihydrochloride (Standard)
  • HY-B1945S1
    DEHP-d38 352431-42-6 98%
    DEHP-d38 is the deuterium labeled DEHP. DEHP (Bis(2-ethylhexyl) phthalate) is an endogenous metabolite.
    DEHP-d38
  • HY-B2176AR
    ATP disodium trihydrate (Standard) 51963-61-2 98%
    ATP (disodium trihydrate) (Standard) is the analytical standard of ATP (disodium trihydrate). This product is intended for research and analytical applications. ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation.
    ATP disodium trihydrate (Standard)
  • HY-CE00663
    3,4,4-Trimethylhepta-2,5-dienoyl-CoA 98%
    3,4,4-Trimethylhepta-2,5-dienoyl-CoA (3,4,4-Trimethylhepta-2,5-dienoyl-coenzyme A) is a multi-methyl-branched fatty acyl-CoA.
    3,4,4-Trimethylhepta-2,5-dienoyl-CoA
  • HY-CE00896
    3-Hydroxyadipyl-CoA 25157-96-4 98%
    3-Hydroxyadipyl-CoA (3-Hydroxyadipoyl-coenzyme A) is a coenzyme A derivative.
    3-Hydroxyadipyl-CoA
  • HY-D0227AR
    THAM hydrochloride (Standard) 1185-53-1
    THAM (hydrochloride) (Standard) is the analytical standard of THAM (hydrochloride). This product is intended for research and analytical applications. THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range.
    THAM hydrochloride (Standard)
  • HY-D0885BR
    Phosphocreatine disodium (Standard) 922-32-7
    Phosphocreatine (disodium) (Standard) is the analytical standard of Phosphocreatine (disodium). This product is intended for research and analytical applications. Phosphocreatine (disodium) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway..
    Phosphocreatine disodium (Standard)
Cat. No. Product Name / Synonyms Application Reactivity